Further Evaluate the Risks
Find out more about the risks associated with agonists and fully evaluate your patients before selecting an ADT.
NEARLY 1 IN 3 MEN WITH PROSTATE CANCER ARE AFFECTED BY AT LEAST ONE COMORBIDITY; 50% OF WHICH ARE CARDIOVASCULAR RELATED3
Ensure that cardiovascular risk factors such as cigarette smoking, high blood pressure, high cholesterol, high blood sugar, and being overweight are managed according to current clinical practice.2,4,5
In 2010, the FDA added warnings and precautions to THE LABELS FOR LHRH agonists regarding a small but statistically significant increased risk of certain cardiovascular diseases and diabetes in men receiving these medications.2
Not all ADTs carry these warnings. Carefully evaluate your patients’ health history and comorbidities, then weigh the risks of certain ADTs before determining treatment.2
Find out more about the risks associated with agonists and fully evaluate your patients before selecting an ADT.
See more on the FDA safety communication to manufacturers about ADT risk factors.
ADT = androgen deprivation therapy; LHRH = luteinizing hormone-releasing hormone.
References: 1. National Comprehensive Cancer Network®. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Prostate Cancer. V2.2017. http://www.nccn.org/professionals/physician_gls/pdf/prostate.pdf. Accessed August 18, 2017. 2. Food and Drug Administration. FDA Drug Safety Communication: update to ongoing safety review of GnRH agonists and notification to manufacturers of GnRH agonists to add new safety information to labeling regarding increased risk of diabetes and certain cardiovascular diseases. http://www.fda.gov/Drugs/DrugSafety/ucm229986.htm. Accessed April 24, 2017. 3. Edwards BK, Noone AM, Mariotto AB, et al. Annual report to the nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer. 2014;120(9):1290-1314. 4. Centers for Disease Control and Prevention. Conditions that Increase risk for heart disease. https://www.cdc.gov/heartdisease/conditions.htm. Updated August 10, 2015. Accessed September 20, 2017. 5. Centers for Disease Control and Prevention. Heart disease behavior. https://www.cdc.gov/heartdisease/behavior.htm. Updated August 10, 2015. Accessed September 20, 2017.